Abstract
BackgroundInfantile colic is a distressing condition characterised by excessive crying in the first few months of life. The aim of this research was to update the synthesis of evidence of complementary and alternative medicine (CAM) research literature on infantile colic and establish what evidence is currently available.MethodsMedline, Embase and AMED (via Ovid), Web of Science and Central via Cochrane library were searched from their inception to September 2018. Google Scholar and OpenGrey were searched for grey literature and PROSPERO for ongoing reviews. Published systematic reviews that included randomised controlled trials (RCTs) of infants aged up to 1 year, diagnosed with infantile colic using standard diagnostic criteria, were eligible. Reviews of RCTs that assessed the effectiveness of any individual CAM therapy were included. Three reviewers were involved in data extraction and quality assessment using the AMSTAR-2 scale and risk of bias using the ROBIS tool.ResultsSixteen systematic reviews were identified. Probiotics, fennel extract and spinal manipulation show promise to alleviate symptoms of colic, although some concerns remain. Acupuncture and soy are currently not recommended. The majority of the reviews were assessed as having high or unclear risk of bias and low confidence in the findings.ConclusionThere is clearly a need for larger and more methodologically sound RCTs to be conducted on the effectiveness of some CAM therapies for IC. Particular focus on probiotics in non-breastfed infants is pertinent.Systematic review registrationPROSPERO: CRD42018092966.
Highlights
Infantile colic is a distressing condition characterised by excessive crying in the first few months of life
We reported the standard mean difference (SMD) and 95% confidence intervals (CI) and results of any tests of heterogeneity reported in the relevant meta-analyses
Forty-three full text articles were assessed for eligibility and 16 systematic reviews were included in this overview
Summary
Infantile colic is a distressing condition characterised by excessive crying in the first few months of life. Immaturity of gastrointestinal tract, food allergies, intestinal cramping or excessive gas formation have all been suggested [5], alongside psychosocial causes, e.g. maternal anxiety and maternal-infant bonding issues [6], but its pathophysiology remains unclear. It is considered a self-limiting condition, it can be distressing for both parents and babies
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