Abstract
IgA Nephropathy, a widespread form of Glomerulonephritis , characterized by episodic hematuria associated with the deposition of IgA in the mesangium . It predominately affects males with a ratio of 3:1 , a peaking in 2 nd and 3rd decades of life. Elevated levels of circulating poorly O-galactosylated IgA1 and O-glycan antibodies forms of IgA1 immune complex molecules and its mesangial deposits cause inflammation and glomerular injury. This condition is common in children and young people, and gives rise to asymptomatic microscopic haematuria and sometimes proteinuria. About 5% of patients develop nephrotic syndrome. Usually, however, the prognosis is favourable.
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