An Overview of Oral Thin Film Drug Delivery Systems with Fast Dissolving Films

Abstract

Fast-dissolving oral thin films (OTFs), rather than tablets, are the product of choice for many pharmaceutical businesses. The benefits of tablets (precise dose, simple administration) and liquid dosage forms (easily swallowed, quick bioavailability) are all present in films. Four out of five patients, according to statistics, prefer orally disintegrating dose forms over traditional solid oral dosage forms. Children, the elderly, people who are bedridden, people who are emetic, and those who have CNS illnesses have trouble swallowing or digesting solid dose forms. Many of these individuals refuse to take solid dose forms because they are afraid of choking. OTFs are immediately moistened by saliva when put on the tongue's tip or base. Because of this, OTFs quickly hydrate before dissolving or disintegrating to release the drug for local or systemic absorption. This technology offers a solid foundation for the creation of patent-compliant items and for extending the patent protection of currently available goods. Fast-dissolving oral thin films can be used for a variety of purposes, including gastroprotective and sublingual delivery systems in addition to buccal fast-dissolving systems. This study emphasizes the composition, detailing the numerous natural and synthetic polymer kinds, diverse manufacturing processes, packaging materials, and assessment tests for OTFs.