Abstract

Nanomaterials have gained tremendous significance as contrast agents for both anatomical and functional preclinical bio-imaging. Contrary to conventional medical practices, molecular imaging plays an important role in exploring the affected cells, thus providing precision medical solutions. It has been observed that incorporating nanoprobes improves the overall efficacy of the diagnosis and treatment processes. These nano-agents and tracers are therefore often incorporated into preclinical therapeutic and diagnostic applications. Multimodal imaging approaches are well equipped with nanoprobes to explore neurological disorders, as they can display more than one type of characteristic in molecular imaging. Multimodal imaging systems are explored by researchers as they can provide both anatomical and functional details of tumors and affected tissues. In this review, we present the state-of-the-art research concerning multimodal imaging systems and nanoprobes for neuroimaging applications.

Highlights

  • The success of medicine and healthcare is largely determined by the efficacy of treatment techniques

  • We provide a comprehensive overview of the nanoprobes/tracers used for neuroimaging applications and the context in which they are used, classified as per the multimodal combinations as Positron Emission Tomography (PET)-Computed Tomography (CT), PET-Magnetic Resonance Imaging (MRI) and Single-Photon Emission Computed Tomography (SPECT)-CT

  • This paper provided an overview of the latest developments in the field of multimodal neuroimaging using nanoprobes, in combination with functional and anatomical imaging

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Summary

Introduction

The success of medicine and healthcare is largely determined by the efficacy of treatment techniques. Imaging systems serve as an excellent diagnostic tool by capturing the details of the disease and therapeutic process on injecting bio-chemical agents or nanoprobes. Several imaging techniques have been developed over time to study the effects of therapeutic agents [6]. Images may be captured at different time intervals using different modalities within the asynchronous model of acquisition for which effective post-processing solutions should be developed. This marriage between therapeutics and diagnostics, as well as the choice of imaging systems, is greatly influenced by the design of the nano-imaging agents.

Multimodal Imaging with Nanoprobes
Discussion and Future
Conclusions
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