Abstract
Lung cancer incidence and mortality have significantly increased in women worldwide. Lung adenocarcinoma is the most common form of lung cancer globally. This type of lung cancer shows differences by sex, including the mutational burden, behavior, clinical characteristics, and response to treatment. The effect of sex on lung cancer patients' survival is still controversial; however, lung adenocarcinoma is considered a different disease in women and men. Moreover, lung adenocarcinoma is strongly influenced by estrogen and is also different depending on the hormonal status of the patient. Young pre-menopausal women have been explored as an independent group. They presented in more advanced stages at diagnosis, exhibited more aggressive tumors, and showed poor survival compared to men and post-menopausal women, supporting the role of sex hormones in this pathology. Several reports indicate the estrogen's role in lung carcinogenesis and tumor progression. Thus, there are currently some clinical trials testing the efficacy of antihormonal therapy in lung cancer treatment. This mini review shows the updated data about lung cancer in women, its characteristics, the etiological factors that influence carcinogenesis, and the critical role of estrogen in lung cancer and treatment.
Highlights
Lung cancer in women (LCW) is a severe health problem globally
Hormonal status is rarely considered in studies; when pre-menopausal women have been studied independently, they were more commonly diagnosed in advanced stages, exhibited less differentiated tumors, and showed a higher number of metastases and poor prognosis compared to post-menopausal women and men [15,16,17,18]
The results showed improved overall survival in non-small cell lung cancer (NSCLC) patients with a mean of 65.5 weeks in those with higher ERβ tumor expression [86]
Summary
Lung adenocarcinoma is the most common form of lung cancer globally This type of lung cancer shows differences by sex, including the mutational burden, behavior, clinical characteristics, and response to treatment. Young pre-menopausal women have been explored as an independent group They presented in more advanced stages at diagnosis, exhibited more aggressive tumors, and showed poor survival compared to men and post-menopausal women, supporting the role of sex hormones in this pathology. There are currently some clinical trials testing the efficacy of antihormonal therapy in lung cancer treatment. This mini review shows the updated data about lung cancer in women, its characteristics, the etiological factors that influence carcinogenesis, and the critical role of estrogen in lung cancer and treatment
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