An Overview of Drug Effects on Bone Healing on Animal Research Models

Naruepon Kampa,Nguyen Hoai Nam

doi:10.31817/vjas.2021.4.1.08

Abstract

Bone fracture is a common health problem in humans and animals, and the healing of the bone fracture is a complicated process. Several drugs may be used concurrently with the treatment of fractures, but they may interfere with the healing process of the bone. The present research reviewed previously published studies with the objective to enhance the understandings of the effects of different drugs on bone healing. There is clear evidence that antibiotics, corticosteroids, non-steroidal inflammatory drugs, and chemotherapeutic drugs all affect bone healing. By contrast, the effect of anticoagulants on bone healing is controversial, so more research is needed to determine its efficacy. In addition, there is no direct evidence to approve the effect of anesthetics on bone healing, so this is another area in need of further research.

Highlights

Bone fracture causes harmful effects to patients’ health, degrades their quality of life, and is responsible for costly treatments
High doses are recommended for oncological treatment, and low doses are for chronic inflammation (Cavalcanti et al, 2014)
The negative effects of several antibiotics and steroids on bone healing may be due to their high doses and/or long treatments because such effects were absent when normal doses and treatment periods were applied

Summary

Introduction

Bone fracture causes harmful effects to patients’ health, degrades their quality of life, and is responsible for costly treatments. The negative effects of antibiotics on bone healing may be due to their high doses such as 100 mg/kg/day for cefuroxime (NatividadPedreno et al, 2016) and ciprofloxacin (Huddleston et al, 2000), 70 mg/kg/day for trovafloxacin and 50 mg/kg/day for levofloxacin (Perry et al, 2003), and due to long treatment durations, such as 3-4 weeks (Huddleston et al, 2000; Perry et al, 2003; Natividad-Pedreño et al, 2016).

Results

Conclusion