Abstract
Hepatocellular carcinoma (HCC) is the third most common cause of cancer mortality worldwide. Although most HCCs seem to originate from the accumulation of genetic abnormalities induced by various risk factors, underlying mechanisms of hepatocarcinogenesis remain unclear. Long-term survival of HCC patients is also poor, partly due to HCC recurrence. Although serum alpha-fetoprotein (AFP) level is a useful marker for the detection and monitoring of HCC, AFP levels may remain normal in the patients even with advanced HCC. To identify useful biomarkers for HCC, many studies have been conducted on molecular events such as genetic and epigenetic alterations, and gene expression. This review summarizes recent studies of potential molecular markers for diagnosis and monitoring metastasis or recurrence of HCC.
Highlights
Hepatocellular carcinoma (HCC) is the third most common cause of cancer mortality worldwide, and liver cirrhosis is the most important predisposing factor for it [1]
Most HCCs seem to be originated from the Cancers 2010, 2 accumulation of genetic abnormalities induced by various risk factors, underlying mechanisms of hepatocarcinogenesis remain unclear
This review summarizes recent studies of potential molecular markers for diagnosis and monitoring metastasis or recurrence of HCC
Summary
Hepatocellular carcinoma (HCC) is the third most common cause of cancer mortality worldwide, and liver cirrhosis is the most important predisposing factor for it [1]. Most HCCs seem to be originated from the Cancers 2010, 2 accumulation of genetic abnormalities induced by various risk factors, underlying mechanisms of hepatocarcinogenesis remain unclear. Serum alpha-fetoprotein (AFP) level is a useful marker for the detection and monitoring of HCC, AFP levels may remain normal in up to 30%. To improve HCC prognosis, it is imperative to find useful markers for early diagnosis and monitoring of recurrence of HCC. To identify candidate biomarkers for HCC, many studies have been conducted on molecular events such as genetic and epigenetic alterations, and gene expression.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
