Abstract
With the growing demands for personalized medicine and medical devices, nanomedicine is a modern scientific field, and research continues to apply nanomaterials for therapeutic and damaged tissue diagnosis. In this regard, substantial progress has been made in synthesizing magnetic nanoparticles with desired sizes, chemical composition, morphologies, and surface chemistry. Among these materials, nanomagnetic iron oxides have demonstrated promise as unique drug delivery carriers due to cancer treatment. This carrier could lead to responsive properties to a specific trigger, including heat, pH, alternative magnetic field, or even enzymes, through functionalization and coating of magnetic nanoparticles, along with biocompatibility, good chemical stability, easy functionalization, simple processing, and ability to localize to the tumor site with the assistance of external magnetic field. Current studies have focused on magnetic nanoparticles’ utilities in cancer therapy, especially for colorectal cancer. Additionally, a bibliometric investigation was performed on the public trends in the field of the magnetic nanoparticle to drug delivery and anticancer, which represented progressing applications of these carriers in the multidisciplinary zones with a general view on future research and identified potential opportunities and challenges. Furthermore, we outline the current challenges and forthcoming research perspective for high performance and fostering advanced MNPs in colorectal cancer treatment.Graphical
Highlights
The efficacy of conventional chemotherapy has been decreased by the non-specific distribution and rapid clearance of anticancer drugs, low efficiency, drug resistance at the cellular and tumor level, and every so often considerable toxicity of common anticancer agents when prescribed at higher doses
This review aims to comprehensively cover recent advances in the field of pure or modified Magnetic nanoparticles (MNPs) with noncovalently or covalently attached drugs for colorectal cancer treatment
Various therapeutic procedures based on magnetic nanocarriers for CRC treatment are currently under development, which was included in MNPs carriers and its sophisticated stimuli-responsive classification in both in vitro and in vivo studies
Summary
Background The development of an effective disease treatment has been a significant goal of the human for more than a millennium. Of progress suggest chances produce sophisticated selectivity targeted-nanomedicines based on carriers and carriers conjugated with numerous biologically active compounds such as nucleotides, drugs, enzymes, genes, or proteins Such materials could potentially form the basis of very specific, safe, and efficient cancer treatments [12]. Current drawbacks of conventional cancer therapies are biological barrier clearance [27], poor bio-distribution [28], and non-specific drug delivery mode of action [29], limiting overall effectiveness [30–34] Nanotechnology can overcome these obstacles through engineered nanomedicine as nanoparticle conjugated drugs [35]. According to the publication trend identified, research in using MNPs in systemic drug delivery for CRC treatment is a hotspot; this section would offer an overview of the current status and future directions in this field. Record identified throughout database including:Google Scholar 1690, Scopus 963, WOS 177, PubMed 33 searching n= 2863
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