Abstract
Heparin-induced thrombocytopenia is a rare and life-threatening condition of exposure to heparin. A case of heparin-induced thrombocytopenia due to the low molecular weight heparin was presented. Pulmonary emboli and progressively decreased number of thrombocytes developed during the low molecular weight heparin treatment. For that reason, the heparin-induced thrombocytopenia was diagnosed. The heparin was ceased and fondaparinux treatment initiated. Platelet levels returned to normal limits within six days. The delaying in diagnosis of heparin-induced thrombocytopenia causes serious outcomes. The physician must be careful and keep in mind be developed of this clinical condition in patient under heparin treatment.
Highlights
Heparin-induced thrombocytopenia (HIT) is an immunemediated, life-threatening condition of exposure to heparin that occurs in a small percentage of patients exposed, regardless of the dose or administration [1]
IV antibiotics and fluid retention were administered and so clinical improvement achieved. She has received the 6th cycle of chemotherapy and after 10 days of accomplished cycle, she underwent examination and laboratory results indicated that her platelet count declined to 9000/mm3 and the thrombocytopenia was revealed
Heparin-induced thrombocytopenia should be suspected in the patients who are currently receiving heparin or who received heparin and develops new onset of thrombocytopenia, a decrease in platelet count by 50 percent or more, even if the platelet count exceeds 150.000/μL, venous or arterial thrombosis, necrotic skin lesions at heparin injection sites and acute systemic reactions occurring after intravenous heparin administration [6,7]
Summary
Heparin-induced thrombocytopenia (HIT) is an immunemediated, life-threatening condition of exposure to heparin (unfractionated heparin; UFH or low molecular weight heparin; LMWH) that occurs in a small percentage of patients exposed, regardless of the dose or administration [1]. The following day of interval surgery, LMWH (4000 Anti-Xa IU/0.4 MI) was initiated for prophylaxis and the patient was discharged with the follow-up arrangements. IV antibiotics and fluid retention were administered and so clinical improvement achieved She has received the 6th cycle of chemotherapy and after 10 days of accomplished cycle, she underwent examination and laboratory results indicated that her platelet count declined to 9000/mm and the thrombocytopenia was revealed. She was accepted as chemotherapy-responsive based on the examinations she has undergone after 6th cycle of chemotherapy and planned 3rd chemotherapy cycle of the interval debulking surgery was decided not to be given She was hospitalized after 47 days of the 6th cycle of chemotherapy due to infection.
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