An outline on curcumin: Its pro-liposome and liposome formulations

Abstract

Curcumin (Cur) is broadly accepted for its useful functions. Cur has low water solubility therefore its application in drug delivery became a challenge for researchers. To overcome the absorption, bioavailability and overall biochemical/structural degradation we may develop pro-liposomes and liposomes of Cur. The proliposomes generally administrated by orally, topically and parentally and mainly used in cosmetic and hair technologies, diagnostic purpose, sustained release formulations and as good carriers in gene delivery. This review highlights the speculative approach and some new advancement for the preparation of pro-liposomes in general. Various methods to formulate pro-liposomes (Film-deposition carrier method, Spray drying method, Fluidized-bed method, Supercritical anti-solvent method), evaluation parameters (Hydration study, Zeta potential, Flow property) there of and applications of pro-liposome are highlighted. This may help for further preparation and evaluation of Cur. based formulations. Additionally different features of curcumin related to its pharmacological profile and mechanism of protection in various ailments have been reported.