Abstract
BackgroundWe report a nosocomial outbreak caused by Burkholderia cepacia that occurred among six patients admitted in the medical and surgical intensive care unit between 04 March 2019 and 02 April 2019 in Istanbul, Turkey.MethodsThe outbreak investigation was launched on 11 March 2019 five days after the detection of B. cepacia in four different patients. We defined potential reservoirs and started environmental screening. We sampled the liquid solutions used in patient care activities. Pulse-field gel electrophoresis (PFGE) was performed to determine the genetic relatedness of environmental and patient samples.ResultsBurkholderia cepacia was isolated in tracheal aspiration cultures of six patients. Three out of six patients developed healthcare-associated pneumoniae due to B. cepacia. Environmental cultures in the ICUs revealed B. cepacia growth in 2% chlorhexidine-gluconate mouthwash solution that been used in the colonized patients as well as in samples obtained from the unused products. PFGE revealed the patient and a specific batch of chlorhexidine mouthwash solution samples had a 96% similarity.ConclusionContamination of medical solutions used in critical patient care could cause outbreaks and should be detected early by infection control teams.Graphic abstract
Highlights
Burkholderia cepacia is an aerobic, gram-negative, nonfermentative bacteria frequently isolated from water and solutions [1]
The patient was diagnosed with ventilator-associated pneumonia (VAP) due to B. cepacia, and treatment with
The investigation revealed a batch of unopened 2% CHG mouthwash solution was the source of this B. cepacia outbreak
Summary
Burkholderia cepacia is an aerobic, gram-negative, nonfermentative bacteria frequently isolated from water and solutions [1]. It can survive in fluids, antiseptic solutions, and the healthcare environment for long durations. Burkholderia cepacia complex is significant in cystic. We describe a nosocomial outbreak caused by Burkholderia cepacia between 04 March and 02 April 2019 in a tertiary care center in Istanbul, Turkey. The outbreak occurred in patients admitted in intensive care units (ICU) with and without structural lung disease. We report a nosocomial outbreak caused by Burkholderia cepacia that occurred among six patients admitted in the medical and surgical intensive care unit between 04 March 2019 and 02 April 2019 in Istanbul, Turkey
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