Abstract
IntroductionOsseous involvement of Hodgkin's lymphoma is uncommon. When osteolytic lesions are seen on imaging it is important to evaluate potential other causes.Case presentationWe report the case of a 10-year-old Caucasian boy who presented to our facility with a bony lesion of the right clavicle and enlarged cervical lymph nodes. A simultaneous biopsy of the lymph node and of the osteolytic process of his right proximal clavicle was performed and revealed two different kinds of lesions: a mixed cellularity Hodgkin's lymphoma and an osteochondroma.ConclusionsSince the latter is a common benign bone tumor, which should not interfere with the staging of the lymphoma, we emphasize the importance of ensuring that all efforts are made to acquire a diagnostic biopsy of all atypical lesions.
Highlights
Osseous involvement of Hodgkin’s lymphoma is uncommon
Since the latter is a common benign bone tumor, which should not interfere with the staging of the lymphoma, we emphasize the importance of ensuring that all efforts are made to acquire a diagnostic biopsy of all atypical lesions
Two-thirds of lymphomas diagnosed in children are non-Hodgkin’s lymphomas (NHL), with the remainder being Hodgkin’s lymphomas (HL)
Summary
Lymphoma is the third most common childhood malignancy following leukemia and brain tumors, accounting for approximately 12% of childhood cancers. Case presentation Due to enlarged lymph nodes in his right neck region, a 10-year-old Caucasian boy underwent ultrasonic investigation and was treated with a short course of antibiotics 18 months prior to his presentation at our facility. Two months before his current admission, our patient reported local pain and enlargement of the same area in the neck. A computed tomography (CT) scan of the neck, thorax and abdomen confirmed a heterogeneous mass of enlarged lymph nodes on the right side of the neck and an osteolytic process accompanied by a periosteal (and soft-tissue) reaction in the right proximal clavicle, conspicuous for a tumor or chronic osteomyelitis (Figure 1). Our patient underwent four courses of ABVD chemotherapy protocol (doxorubicin, bleomycin, vinblastine and dacarbazine) for stage IIa disease and is currently five years on from cessation of all treatment and in complete remission
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