Abstract
Tandem mass spectrometry is an important tool for structure elucidation of natural and synthetic organic products. Fragmentation of odd electron ions (OE+) generated by electron ionization (EI) was extensively studied in the last few decades, however there are only a few systematic reviews available concerning the fragmentation of even-electron ions (EE+/EE−) produced by the currently most common ionization techniques, electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI). This review summarizes the most important features of tandem mass spectra generated by collision-induced dissociation fragmentation and presents didactic examples for the unexperienced users.
Highlights
Electron ionization (EI), a hard ionization technique, is the method of choice for analyses of small (
The technique involves ionization by electrons with ~70 eV energy. This energy is high enough to yield very reproducible mass spectra with a large number of fragments. These spectra frequently lack the radical type molecular ions (M+ ) due to the high internal energy transferred to the precursors [1]
Protonated initial molecules selected for called precursor ions, while their fragments cleavages which are rare amongst thisfragmentation type of ions.are
Summary
Electron ionization (EI), a hard ionization technique, is the method of choice for analyses of small (
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