Abstract
An orbital perturbation approach of enzymatic catalysis is proposed. Orbital symmetry restrictions to a fast reaction pathway is lifted by first order perturbation of the catalyst potential. The drastic decrease of the energy gap is a second order effect enhance by the band-like structure of the enzymes. The model incorporates conformational specify and signals the importance of the low symmetries of the active sites. It is proposed that allosteric effects are due to shifts of the enzyme band structure.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.