Abstract

An oral gelatin-xylose test is proposed as a practical test for pancreatic proteolytic activity. The principal function of the xylose test is to support the adequacy of small-bowel absorption and thus allow for the more confident interpretation of protein digestion. It was found that, following gelatin ingestion, the normal adult increases his urinary total hydroxyproline excretion by a mean of 7.7 mg./hr. Values falling below 3.3 mg./hr. after a test meal are considered abnormal. A practical short testing period in children is feasible because of the rapid renal clearance of the absorbed hydroxyproline peptides. These peptides are the principal form of urinary hydroxyproline.

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