Abstract
Drug release is a crucial process in treatment. Conventional drug administration requires patient’s compliance and has the risk of overdosing. In order to control drug release, several potential materials are develo0ped. In this paper, we focus on hydrogel material and simulate drug release process in MATLAB. We optimize the parameter for a seven-day release of a drug. The results show that the diffusion coefficient at approximately 4.00E−11 could ensure medicine to diffuse around 7 days and maintain its effects.
Highlights
Drugs are administrated orally or intravenously in multiple doses at particular frequency to attain the desired therapeutic concentration of drug in plasma and maintain it for the entire duration of treatment
We focus on hydrogel material and simulate drug release process in MATLAB
The therapeutic window is 0.5 so we have to compare the diffusion coefficient of several types of hydrogel and make it bigger than 0.5. we selected four diffusion coefficients which each are smaller than the previous ones, the first one is Agar gel in selfish poison with the diffusion coefficient 0.48 × 10−5 and rt/r0 is smaller than 0.5 so it is not an appropriate diffusion coefficient which is corresponding to the therapeutic window of vancomycin
Summary
Drugs are administrated orally or intravenously in multiple doses at particular frequency to attain the desired therapeutic concentration of drug in plasma and maintain it for the entire duration of treatment. The dosing interval is much shorter than the half-life of a drug, resulting in limitations such as poor patient compliance, potential increased toxicity due to peak plasma concentration and fluctuating drug level It is even more challenging in treating infections in relatively less vascular tissues (e.g., bones) and avascular tissues (e.g., cartilages) because of the limited penetration of antibiotics into the target sites. To overcome the limitations of conventional dosage form and increase the safety and efficiency of drug release, controlled drug delivery systems have been investigated extensively in the past few decades [1] [2] [3] [4]. Vancomycin is an antibacterial drug used for penicillin-allergic patients or severe infection caused by susceptible strains of methicillin-resistant (β-lactam resistant) staphylococci It is poorly absorbed by oral administration [23]
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