Abstract
Prostate cancer disease is one of the common types that cause men's prostate damage all over the world. Prostate-specific membrane antigen (PSMA) expressed by type-II is an extremely attractive style for imaging-based diagnosis of prostate cancer. Clinically, photodynamic therapy (PDT) is used as noninvasive therapy in treatment of several cancers and some other diseases. This paper aims to segment or cluster and analyze pixels of histological and near-infrared (NIR) prostate cancer images acquired by PSMA-targeting PDT low weight molecular agents. Such agents can provide image guidance to resection of the prostate tumors and permit for the subsequent PDT in order to remove remaining or noneradicable cancer cells. The color prostate image segmentation is accomplished using an optimized image segmentation approach. The optimized approach combines the k-means clustering algorithm with elbow method that can give better clustering of pixels through automatically determining the best number of clusters. Clusters' statistics and ratio results of pixels in the segmented images show the applicability of the proposed approach for giving the optimum number of clusters for prostate cancer analysis and diagnosis.
Highlights
As per the American Cancer Society [1], in 2020, the United States is relied upon to have 191,930 new instances of prostate disease, and the number of deaths due to prostate malignancy will reach 33,330 [2]
In Saudi Arabia for years between 2001 and 2008, there are 7.7 per 100,000 men, and 5.1 per 100,000 men were estimated as prostate cancer of the agestandardized incidence rate (ASIR) and the age-standardized mortality rate (ASMR), respectively, by the International Agency for Research on Cancer (IARC) [6]
Reliable segmentation of prostate images is important for radiologists to analyze and detect disease
Summary
As per the American Cancer Society [1], in 2020, the United States is relied upon to have 191,930 new instances of prostate disease, and the number of deaths due to prostate malignancy will reach 33,330 [2]. E number of prostate cancer patients who have been treated is increasing significantly [4]. In 2014, the report issued by Data of Saudi Cancer Registry has exposed that the rank of prostate cancer was the fifth and creates 6.1% of overall cancers in men in the Saudi Arabia [5]. In Saudi Arabia for years between 2001 and 2008, there are 7.7 per 100,000 men, and 5.1 per 100,000 men were estimated as prostate cancer of the agestandardized incidence rate (ASIR) and the age-standardized mortality rate (ASMR), respectively, by the International Agency for Research on Cancer (IARC) [6]. Neuman et al [7] have exposed improving the prostate cancer surgical treatment and reducing the margins of positive surgical rate by the near-infrared (NIR) fluorescence probe YC-27 in real time laparoscopic extirpative surgery
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
