Abstract
AimsThe aim of the present study was to determine the optimal initial tension for the rat basilar artery when using wire myography. MethodsRat basilar arteries were mounted in myograph baths. A normalization procedure was performed. K+-rich (60mM) buffer solution-induced tension was measured in different initial tensions. ResultsThe initial tension of the basilar artery increased from 0.47 to 2.68mN/mm. Contractile tension was also elevated along with the initial tension. When the initial tension reached 1.63mN/mm, K+-induced contractile tension of basilar artery achieved its maximum. Thereafter, contractile tension declined as initial tension increased. The duration of equilibration time did not affect K+-induced contractile tension. ConclusionThe optimal initial tension is 1.63±0.01mN/mm in rat basilar arteries when using wire myography.
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