An optically active chromium(0)-complexed benzaldehyde in organic synthesis: A highly stereocontrolled asymmetric synthesis of (2R,3S)-(−)- N-benzoyl-3-phenylisoserine methyl ester, the taxol C-13 side chain analogue

Abstract

An asymmetric aldol reaction of (+)-chromium(0)-complexed benzaldehyde 4 with the titanium enolate generated from the ethanethioate 5 provided the anti-aldol product 6 in a highly stereoselective manner, which was subsequently converted to the taxol C-13 side chain.