Abstract
QoolSkin is novel herbal topical medication indicated for the treatment of patients with psoriasis and we endeavored to determine the efficacy of QoolSkin in patients with chronic plaque psoriasis. In an open-label, parallel-group study conducted at four sites in Israel, patients with chronic plaque psoriasis were treated by application of QoolSkin two to three times per day, for a period of 16 weeks. Clinical assessment was performed using the Psoriasis Area and Severity Index (PASI) and the Beer-Sheva Psoriasis Severity Score (BPSS). The study included 100 patients (48 men, 52 women; age 18–65 years). QoolSkin was well tolerated and there were no local or systemic side effects. There was a 19% reduction in PASI, from a mean of 9.8 ± 9.5 before treatment to 8.0 ± 9.6 after treatment (p = 0.09). There was a 20% reduction in BPSS, from a mean of 16.1 ± 9.8 before treatment to 12.8 ± 10.6 after treatment (p = 0.01). The reduction in PASI and BPSS was pronounced in women (32 and 31%, respectively) as compared to men (9 and 11%, respectively). The reduction in PASI and BPSS was parallel to the length of time the patients were treated by QoolSkin. In patients treated by one of the investigators, who applied QoolSkin three times per day and for a long period of time (mean 101.1 days), the reduction in PASI was 32.0% and the reduction in BPSS was 37.8%. In patients with chronic plaque psoriasis, QoolSkin treatment was well tolerated. Application of QoolSkin was associated with a decrease in disease severity, as assessed by the patients and physicians. Application of QoolSkin three times per day for long period is associated with a better response to treatment.
Highlights
Psoriasis is a chronic disorder characterized by erythematous scaly patches that affect the scalp, trunk, extensor surfaces of the limbs, and the genital area
The primary objective of this study was to determine the efficacy of QoolSkin topical treatment in patients with chronic plaque psoriasis
The reduction in Psoriasis Area and Severity Index (PASI) and Beer-Sheva Psoriasis Severity Score (BPSS) was pronounced in women (32 and 31%, respectively) as compared to men (9 and 11%, respectively) (Table 2)
Summary
Psoriasis is a chronic disorder characterized by erythematous scaly patches that affect the scalp, trunk, extensor surfaces of the limbs, and the genital area. Psoriasis is highly prevalent in the general population, mainly as a result of its chronicity and the absence of a cure. Patients with psoriasis have high rates of depression and a decreased quality of life. Patients with mild to moderate psoriasis are usually treated. Cohen et al.: Herbal Medication for Psoriasis. Systemic therapy or phototherapy are reserved for patients with moderate to severe disease[1,2,3,4]. Recent studies described the role of complementary and alternative medicine in patients with psoriasis, including mind-body interventions, herbal medicine, nutrition, and traditional Chinese medicine[5,6,7,8,9,10,11,12,13,14,15,16,17,18]. In a recent study by Ben-Arye et al.[19], it was shown that 18% of Israeli patients with psoriasis used homeopathic medicines
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