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Abstract
Current, commercial, electrode micro-drives that allow independent positioning of multiple electrodes are expensive. Custom designed solutions developed by individual laboratories require fabrication by experienced machinists working in well equipped machine shops and are therefore difficult to disseminate into widespread use. Here, we present an easy to assemble modular micro-drive system for acute primate neurophysiology (PriED) that utilizes rapid prototyping (3-d printing) and readily available off the shelf-parts. The use of 3-d printed parts drastically reduces the cost of the device, making it available to labs without the resources of sophisticated machine shops. The direct transfer of designs from electronic files to physical parts also gives researchers opportunities to easily modify and implement custom solutions to specific recording needs. We also demonstrate a novel model of data sharing for the scientific community: a publicly available repository of drive designs. Researchers can download the drive part designs from the repository, print, assemble and then use the drives. Importantly, users can upload their modified designs with annotations making them easily available for others to use.
Highlights
Single-neuronal studies remain the gold-standard of understanding how our brains encode and process information
Researchers have developed innovative microdrive solutions that allow for multi-neuron recordings in both acute [2,3], semi-chronic [4], and chronic preparations [5]. These solutions allow for simultaneous multi-neuron and multi-site recordings, they are either expensive to purchase commercially or are custom-built devices that require experienced machinists working in well equipped model shops to build and assemble
Researchers are able to create custom solutions to explore their experimental questions with unprecedented flexibility
Summary
Single-neuronal studies remain the gold-standard of understanding how our brains encode and process information. Since the late 1960s, researchers have been exploring the activity of individual neurons in awake-and-behaving non-human primates to better understand the neural substrates of cognition and behavior [1]. Despite these advancements, the classic method of inserting a single-probe at a time poses a critical bottleneck for understanding the activity of multiple neurons simultaneously – a more biologically realistic framework. Implanted micro-electrode arrays have come to the fore as a means of simultaneously recording from populations of neurons [6,7]. Deep brain structures such as the basal ganglia and hippocampus remain out of range of arrays
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