Abstract
Abstract not available. Disclosures: Study supported by SUN Pharma. Copyright 2018 SKIN
Highlights
Severe acne is known to have a significant adverse effect on self-esteem and quality of life (QOL).[1]
To evaluate the efficacy and safety of lidose-isotretinoin taken without food by patients with severe recalcitrant nodular acne, in addition to assessing their quality of life
Secondary efficacy endpoints included monthly change from baseline in Acne-QOL scores and lesion counts during the active treatment period (ATP) and change from baseline to end of treatment (EOT) in Investigator’s Global Assessment (IGA) scores
Summary
Severe acne is known to have a significant adverse effect on self-esteem and quality of life (QOL).[1]. With isotretinoin, can subsequently improve the patient’s QOL. The timing of QOL improvement over the course of treatment with lidose-isotretinoin has not been established. Isotretinoin products must be taken with a high-fat meal to achieve optimal absorption. Fasted plasma levels of isotretinoin can be nearly 60% lower than fed levels.[2]. Noncompliance with the food intake requirements can potentially compromise the long-term efficacy of isotretinoin[3]. Absorption of lidose-isotretinoin is less dependent on the amount and/or type of food intake and it can be taken without meals, while still providing a reliable isotretinoin blood concentration[4]
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