Abstract
Recent progress in Omics technologies has started to empower personalized healthcare development at a thorough biomolecular level. Omics have subsidized medical breakthroughs that have started to enter clinical proceedings. The use of this scientific know-how has surfaced as a way to provide a more far-reaching view of the biological mechanisms behind diseases. This review will focus on the discoveries made using Omics and the utility of these approaches for Emery–Dreifuss muscular dystrophy.
Highlights
To understand the complexity of systems biology, Omics’ technologies adopt a holistic view
The scope of this review is to provide an overview of the Omics approaches and their application in Emery–Dreifuss muscular dystrophy research
Omics technologies have hastened the identification of genetic mutations associated with Emery–Dreifuss muscular dystrophy (EDMD), and have unveiled the existence of rare variants and modifier genes that might establish the phenotypical heterogeneity of the disease
Summary
To understand the complexity of systems biology, Omics’ technologies adopt a holistic view. In opposition to hypothesis-generating experiments, no rationale is known, but instead, biological inputs are acquired and analyzed to delineate a hypothesis that can be tested. Omics technology can be used to decipher physiological conditions and in disease states, where they have a key role in diagnosis, as well as promoting our knowledge of the development of diseases [1]. Omics approaches to conditions, such as muscular dystrophies, are being used for small molecule therapy discovery by isolating innovative targets for drug development [2]. The scope of this review is to provide an overview of the Omics approaches and their application in Emery–Dreifuss muscular dystrophy research
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