Abstract
An overwhelming amount of evidence from prospective randomized controlled trials supports the clinical efficacy and safety of cardiac resynchronization therapy (CRT) in patients with moderate or severe heart failure and ventricular dyssynchrony. CRT makes heart failure patients feel better, improves cardiac structure and function, and reduces all-cause as well as heart failure morbidity and mortality. Thus, there may be a clinical mandate for use of CRT in many patients with chronic heart failure. However, most complications were minor and no mortality was reported. Failure of lead placement was the most frequent complication, and cardiac perforation and coronary sinus dissection were the most serious adverse events.
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