Abstract
Background/aim The aim of this study was to investigate the importance of preprocedural uric acid (UA) level in predicting fractional flow reserve (FFR) results of intermediate coronary lesions in patients with stable coronary artery disease undergoing coronary angiography.Materials and methods We retrospectively analyzed 293 patients who underwent FFR measurement to determine the significance of intermediate coronary stenosis detected by conventional coronary angiography. Patients were divided into 2 groups: Group 1 (n = 127) included patients with FFR of <0.80 (hemodynamically significant lesions), and Group 2 (n = 169) consisted of patients with FFR of >0.80 (hemodynamically nonsignificant lesions). Uric acid levels were assessed in both groups with the enzymatic colorimetric method by clinical chemistry autoanalyzer.ResultsThe mean UA level was significantly higher in patients whose FFR indicated hemodynamically significant coronary lesions (UA: 5.43 ± 1.29 mg/dL in Group 1 vs. 4.51 ± 1.34 mg/dL in Group 2, P < 0.001).Conclusion Elevated UA levels are associated with hemodynamically significant coronary lesions measured with FFR. Uric acid may be used as a predictor of hemodynamically compromised coronary lesions before FFR procedures.
Highlights
Determining the functional significance of a coronary artery lesion is essential for revascularization decisions and prognosis estimation in patients with coronary artery disease (CAD)
Background/aim: The aim of this study was to investigate the importance of preprocedural uric acid (UA) level in predicting fractional flow reserve (FFR) results of intermediate coronary lesions in patients with stable coronary artery disease undergoing coronary angiography
The mean UA level was significantly higher in patients whose Fractional flow reserve (FFR) indicated hemodynamically significant coronary lesions (UA: 5.43 ± 1.29 mg/dL in Group 1 vs. 4.51 ± 1.34 mg/dL in Group 2, P < 0.001)
Summary
Determining the functional significance of a coronary artery lesion is essential for revascularization decisions and prognosis estimation in patients with coronary artery disease (CAD). Coronary angiography (CAG) plays a crucial role in the assessment of coronary artery stenosis. It is inherently limited in its ability to demonstrate the functional significance of a coronary lesion, in intermediate lesions, defined as those with 50%–70% stenosis [1]. Fractional flow reserve (FFR) is the most accurate method of determining the physiological significance of a coronary lesion and is an important technique in daily cardiology practice [2]. There is growing evidence that elevated UA levels are correlated with both cardiovascular disease and its leading risk factors, such as hypertension [3].
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