An observational study to determine relationship of serum hydrogen sulphide level in hypothyroid patients in a medical college in Kolkata

Abstract

Hypothyroidism is an endocrinopathy eventuate due to destruction of thyroid cells incapacitating synthesis of thyroid hormones. HS which is a gas signaling molecule that might protect synthesis and secretion of thyroid hormone by upregulating the expression levels of thyroid hormone synthesis-related proteins and promotingting Thyroid peroxidase (TPO) activity through S-sulphydration of sirtuin-1 (SIRT-1). Depending on this fact we measured the HS level in a group of hypothyroid patient. The plasma H S level in case in our study was 33.95 ± 4.14 micromol/l with the range from 27.82 to 43.94 micromol/l. This was significantly (P< 0.001) lower than age/sex matched healthy controls which was 64.67±4.25 micromol/l, with a range from 49.81 to 80.02 micromol/l. this study also elucidated that plasma HS levels were significantly correlated with level of diagnostic parameters of hypothyroidism.