An Observational Study on Long Term Safety and Efficacy of Ivabradine in Patients with Chronic Heart Failure

Abstract

The chief objective of the study is to find out the safety and efficacy of ivabradine in patients with chronic heart failure. A prospective observational study has been guided in the cardiology department of tertiary care hospital. The data is collected from the out-patient and in- patient department after considering inclusion and exclusion principles for 6 months and a total of 220 patients were analyzed with data collection form by interviewing to the patients about the Socio-demographic questionnaire, MLHFQ (Minnesota Living and Heart Failure Questionnaire) for the evaluation of safety and efficacy of ivabradine and quality of life after Heart Failure. Statistical tools like the Chi-square test were applied to the data by using SPSS software. A total amount of 220 Heart Failure patients, males 148 (67.3%) patients were predominant over female patients of 72 (32.7%). The majority of the Heart Failure patients were under the peer group of >60 years (100%), symptoms were more in males (46%), past medical history i.e. Hypertension and Diabetes mellitus were more in number (128), Coronary Artery Disease (Anterior Wall Myocardial Infraction) (32), Non ST Elevated Myocardial Infraction (8). Most of the patients were treated with the dose of ivabradine i.e. 5mg rather than 2.5mg or 7.5mg. Among 5mg (90.9%), 2.5mg (5.5%) and 7.5mg (3.6%). The ivabradine is used for decreasing Heart Rate among all age groups i.e. >35 years are having more Heart Rate before ivabradine intake. After ivabradine intake, the normal Heart Rate is seen in age groups of 35- 40 years. Adverse effects of ivabradine are bradycardia (10%), Hypertension (8.9%), atrial fibrillation (8.3%), and luminous phenomenon (2.8%). Heart Failure is mostly seen in males and elderly people. The present study shows the safety and efficacy with respect to ivabradine in patient with congestive Heart Failure. After intake of ivabradine, the Heart Rate was bought to normal which shows the efficacy of the drug and the adverse effects are bradycardia, hypertension, atrial fibrillation, luminous phenomenon. But these adverse reactions were not seen in the sample size. This shows the safety of the drug.