An observational prospective study of mucocutaneous adverse effects of chemotherapeutic drugs and radiotherapy

Abstract

Background There is an enormous advancement in chemotherapeutic drugs and radiotherapy. With the advancement, the adverse effects in patients receiving chemotherapeutic drugs and radiotherapy have also increased. Hence identifying and treating adverse effects of chemotherapeutic drugs and radiotherapy is of utmost importance for patients. This study will help us to find out the various mucocutaneous adverse effects associated with various new chemotherapeutic drugs and radiation. Our objective is to find out the frequency of mucocutaneous manifestation in patients receiving chemotherapy and radiotherapy and also to know and assess the various patterns and severity of mucocutaneous involvement in chemotherapy and radiotherapy. Methods This will be an observational prospective study that will be conducted in a tertiary care cancer hospital [Siddharth Gupta Memorial Cancer Hospital] and patients coming to OPD of AVBRH in the Department of Dermatology from 15th December 2023 to 15 September 2024, who will be presenting with the mucocutaneous adverse effects. Detailed History and Cutaneous examination will be performed and graded according to Common Terminology Criteria for Adverse Events v5. The various mucocutaneous adverse effects will be compiled and grading will be done. This study will help us to find out the various mucocutaneous adverse effects associated with various new chemotherapeutic drugs and radiation. Results We will study the various mucocutaneous manifestations in patients with solid organ malignancy or hematological malignancy receiving chemotherapy and radiotherapy.