Abstract
While the presence of post-synaptic NMDA receptors in the CNS is well-established, the present study addressed the question of whether NMDA receptors may also be present on secretory nerve endings. Using microspectrofluorometry of fura-2 loaded isolated neurohypophysial nerve endings of the rat, we found that both glutamate (EC 50 = 50 μM) and NMDA (EC 50 = 30 μM) induced a rapid rise in (Ca 2+ i. These responses were glycine-dependent and abolished by 1 MM Mg 2+, 1 μM dizocilpine, and removal of extracellular Ca 2+. Responses were not significantly affected by treatment with Ca 2+ channel blockers or 10 μM M CNQX.
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