An MBoC Favorite: High-resolution whole-genome sequencing reveals that specific chromatin domains from most human chromosomes associate with nucleoli

Abstract

Molecular Biology of the CellVol. 23, No. 11 MBoC 20th Anniversary FavoritesFree AccessAn MBoC Favorite: High-resolution whole-genome sequencing reveals that specific chromatin domains from most human chromosomes associate with nucleoliSui HuangSui HuangSearch for more papers by this authorPublished Online:13 Oct 2017https://doi.org/10.1091/mbc.e12-02-0155AboutSectionsView PDF ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InRedditEmail In celebration of MBoC's first 20 years, members of the Editorial Board, members of the ASCB Council, and others comment on their favorite MBoC papers from the past two decades.This article is my favorite MBoC paper, because I believe that it broke ground for a new field—the study of the role of nucleoli in genome organization. Van Koningsbruggen et al. (2010) demonstrate that parts of all chromosomes are associated with nucleoli in human cells. The association is biased toward more transcriptionally repressive and AT-rich regions of the genome. The patterns of nucleolar-associated chromatins partially overlap with nuclear lamina–associated chromatin domains and are heritable through cell cycles. Nucleoli and nuclear lamina have long been known to nucleate heterochromatin. However, little attention has been directed to exploring possible roles of nucleoli in global genome organization. This article, together with a study published in the same period by Nemeth et al. (2010), provided the first molecular evidence of the extensive interactions between nucleoli and the genome. These findings raise the possibility that nucleoli play a key role in anchoring and organizing the mammalian genome.FOOTNOTESDOI: 10.1091/mbc.E12-02-0155Molecular Biology of the Cell Volume 23 Page 2016.REFERENCES Nemeth A, Conesa A, Santoyo-Lopez J, Medina I, Montaner D, Peterfia B, Solovei I, Cremer T, Dopazo J, Langst G (2010). Initial genomics of the human nucleolus. PLoS Genet 6, e1000889. Crossref, Medline, Google Scholar van Koningsbruggen S, Gierlinski M, Schofield P, Martin D, Barton GJ, Ariyurek Y, den Dunnen JT, Lamond AI (2010). High-resolution whole-genome sequencing reveals that specific chromatin domains from most human chromosomes associate with nucleoli. Mol Biol Cell 21, 3735-3748. Link, Google ScholarFiguresReferencesRelatedDetailsCited byCalreticulin promotes EGF-induced EMT in pancreatic cancer cells via Integrin/EGFR-ERK/MAPK signaling pathway26 October 2017 | Cell Death & Disease, Vol. 8, No. 10 Vol. 23, No. 11 June 01, 20122015-2234 Metrics Downloads & Citations Downloads: 27Citations: 1 History Information© 2012 Huang. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).PDF download