Abstract
The direct action of a potent LHRH agonist, [D-Ser-(TBU) 6, des-Gly-NH 2 10]LHRH ethylamide was studied in porcine granulosa cells in primary culture. The LHRH agonist inhibits by 30 to 55% the stimulatory effect of FSH on cyclic AMP accumulation up to 9 hours of incubation. In the absence of FSH, a more transient inhibitory effect is observed on cyclic AMP levels. The LHRH agonist inhibits both basal and FSH-induced progesterone secretion. The present data suggest that ovarian LHRH receptors are negatively coupled to adenylate cyclase.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
More From: Biochemical and Biophysical Research Communications
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.