An L-lactate Biosensor Based on Printed Organic Inverter Circuitry and with a Tunable Detection Limit

Kuniaki Nagamine,Rei Shiwaku,Daisuke Kumaki,Shizuo Tokito,Hiroyuki Furusawa,Taisei Mano,Hiroyuki Matsui

doi:10.18494/sam.2019.2174

Abstract

An L-lactate Biosensor Based on Printed Organic Inverter Circuitry and with a Tunable Detection Limit

Highlights

The recent development of wearable chemical sensor devices has enabled the daily monitoring of biomarkers from external bodily fluids such as tears, saliva, urine, and sweat.[1,2,3,4,5,6]it is difficult for people with insufficient knowledge about biomarkers to understand their physical conditions from the detected signal
An inverter circuit is a logical gate that outputs reversed logic “zero” or logic “1” against the input of logic “1” or logic “0”, respectively.[16,17,18,19] We considered that, if the input voltage of the inverter circuit can be controlled by the potentiometric output of the enzyme-based biosensor depending on the analyte concentration, the inverter circuit will exhibit steep switching of the output voltage at the threshold concentration of the analyte to induce a clear change in display signage
The device is composed of three basic components: the biosensing cell, which consists of the extended-gate electrode modified with lactate oxidase (LOx)/PB and the Ag/AgCl reference electrode [Fig. 1(c)], a two-stage organic inverter circuit employing

Summary

Introduction

The recent development of wearable chemical sensor devices has enabled the daily monitoring of biomarkers from external bodily fluids such as tears, saliva, urine, and sweat.[1,2,3,4,5,6]. It is difficult for people with insufficient knowledge about biomarkers to understand their physical conditions from the detected signal. Some wearable sensors have been combined with a user-readable display such as an electrochromic[10,11,12,13] or LEDbased display,(14,15) which exhibits subtle color changes depending on the analyte concentration. We have developed a printed organic transistor-based inverter circuit with low operating voltage.[20,21] The printing technology has emerged as a low-cost, environment-friendly mass manufacturing technology for the fabrication of next-generation printed wearable flexible devices based on thin-film transistors.[22,23,24,25,26,27]

Methods

Results

Conclusion