Abstract

An L-lactate Biosensor Based on Printed Organic Inverter Circuitry and with a Tunable Detection Limit

Highlights

  • The recent development of wearable chemical sensor devices has enabled the daily monitoring of biomarkers from external bodily fluids such as tears, saliva, urine, and sweat.[1,2,3,4,5,6]it is difficult for people with insufficient knowledge about biomarkers to understand their physical conditions from the detected signal

  • An inverter circuit is a logical gate that outputs reversed logic “zero” or logic “1” against the input of logic “1” or logic “0”, respectively.[16,17,18,19] We considered that, if the input voltage of the inverter circuit can be controlled by the potentiometric output of the enzyme-based biosensor depending on the analyte concentration, the inverter circuit will exhibit steep switching of the output voltage at the threshold concentration of the analyte to induce a clear change in display signage

  • The device is composed of three basic components: the biosensing cell, which consists of the extended-gate electrode modified with lactate oxidase (LOx)/PB and the Ag/AgCl reference electrode [Fig. 1(c)], a two-stage organic inverter circuit employing

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Summary

Introduction

The recent development of wearable chemical sensor devices has enabled the daily monitoring of biomarkers from external bodily fluids such as tears, saliva, urine, and sweat.[1,2,3,4,5,6]. It is difficult for people with insufficient knowledge about biomarkers to understand their physical conditions from the detected signal. Some wearable sensors have been combined with a user-readable display such as an electrochromic[10,11,12,13] or LEDbased display,(14,15) which exhibits subtle color changes depending on the analyte concentration. We have developed a printed organic transistor-based inverter circuit with low operating voltage.[20,21] The printing technology has emerged as a low-cost, environment-friendly mass manufacturing technology for the fabrication of next-generation printed wearable flexible devices based on thin-film transistors.[22,23,24,25,26,27]

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