An iterative approach to novel polyamines via nucleophilic ring-opening of aziridinium ions with beta-amino alcohols.

Abstract

An iterative procedure for the synthesis of a novel class of synthetic polyamines has been developed, utilising the regioselective ring-opening of aziridinium ion intermediates; facile N-allyl deprotection of intermediate polyamines allows the rapid construction of high molecular weight, stereochemically defined compounds in a convergent manner.