Abstract
AbstractT lymphocytes (T cells) are essential for tumor immunotherapy. However, the insufficient number of activated T cells greatly limits the efficacy of tumor immunotherapy. Herein, we proposed an oncolytic virus‐mimicking strategy to enhance T cell recruitment and activation for tumor treatment. We constructed an oncolytic virus‐like nanoplatform (PolyIC@ZIF‐8) that was degraded in the acidic tumor environment to release PolyIC and Zn2+. The released PolyIC exhibited an oncolytic virus‐like function that induced tumor cell apoptosis and promoted T cell recruitment and activation through a tumor antigen‐dependent manner. More importantly, the released Zn2+ not only enhanced T cell recruitment by inducing CXCL9/10/11 expression but also promoted T cell activation to increase interferon‐γ (INF‐γ) expression by inducing the phosphorylation of ZAP‐70 via a tumor antigen‐independent manner. This Zn2+‐enhanced oncolytic virus‐mimicking strategy provides a new approach for tumor immunotherapy.
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