Abstract
Few iodine balance studies have been conducted in school-age children. This study aimed to conduct an iodine balance study in school-aged children. We measured daily iodine intake, excretion, and retention for three consecutive days without any dietary interventions in school-age children. Linear mixed-effects models were used to fit the relationship between total iodine intake (TII) and iodine retention (IR). 29 children aged 7-12 years (mean age 10.2 ± 1.4 years) with normal thyroid function and thyroid volume (Tvol) were recruited. The zero balance value (iodine intake = iodine excretion, iodine retention = 0 μg/d) shifted with iodine intake in an iodine sufficient population. The zero balance value for school-aged children with an iodine intake of 235 (133, 401) μg/d is 164 μg/d. Children aged 7-12 years with iodine intake >400 μg/d were almost in a positive iodine state. An iodine intake of 235 (133, 401) μg/d for children aged 7-10 years achieved a zero balance value of 164 μg/d. Long-term iodine intake of >400 μg/d is not recommended.
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