Abstract
YidC is a membrane protein that facilitates the insertion of newly synthesized proteins across the membrane. YidC inserts protein into the membrane bilayer via the SecYEG dependent complex, but it can also function as an independent insertase in addition to chaperone activity in protein folding. Several studies have provided evidence of its independent insertion mechanism. This study elucidates the insertion mechanism of YidC at an atomic level through a combination of equilibrium and non-equilibrium molecular dynamics (MD) simulations.
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