Abstract
1. 1. Propylene glycol distearate, labeled with propylene glycol-1-C 14 and with C 14 carboxyl stearate, administered orally to rats was hydrolyzed in the gastrointestinal tract to form propylene glycol monostearate, propylene glycol, and stearic acid. 2. 2. Cannulation of the intestinal lymphatics demonstrated the appearance of radioactivity from propylene glycol distearate in the lymph which is comparable to that appearing in the lymph after feeding glyceryl stearate esters. Only small amounts of free propylene glycol were detected in the lymph. 3. 3. During the process of absorption, propylene glycol distearate is resynthesized from its hydrolytic products and is transported by the lymph. Free stearic acid and propylene glycol monostearate were not detected in the lymph. 4. 4. The absorption mechanism for propylene glycol distearate is similar to the glyceryl stearate esters.
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