An investigation of the impact of Kelussia odoratissima extract on mice with secondary hyperlipidemia

Abstract

Introduction: For many years, human beings have applied plants as medicine and their healing impact has been proved for many years. Kelussia odoratissima is a biennial, edible, and fragrant plant with medicinal and food applications. This plant is dedicated to some pastures of Iran and this plant is not reported in other regions around the world. Flavonoids are the most important ingredient of this plant. Materials and Methods: In this study, to evaluate the effect of feeding mice with secondary hyperlipidemia with K. odoratissima, we used thirty mice with secondary hyperlipidemia of similar weight and divided them into three equal groups. For 3 weeks, the first and second groups were fed with the extract of K. odoratissima with doses of 600 mg/kg weight of mice and 1200 mg/kg weight of mice, respectively, and triglyceride, low-density lipoprotein (LDL), total cholesterol, and weight of mice were evaluated. Results: The results showed that, at the end of the 1st week, there was no significant change in any of the groups, but at the end of the 2nd week, in the first group, there was a reduction of LDL; in the second group total cholesterol and triglyceride without any weight change were reduced and LDL factors, total cholesterol, and triglyceride had low weight change; and in the third group, there was an increase of LDL factors, total cholesterol, and triglyceride and an increase of weight. At the end of the 3rd week, in the first group, there was a reduction of LDL factors, total cholesterol, and triglyceride and a little weight reduction; in the second group there was a reduction of LDL factors, total cholesterol, and triglyceride and a considerable reduction of the weight; and in the third group, LDL factors and total cholesterol, triglycerides, and weight of mice were increased. Conclusion and Discussion: Hydroalcoholic extract of the plant reduced total cholesterol, triglyceride, LDL, and weight of mice using K. odoratissima. Except two groups that were administered K. odoratissima, the weight of the other animals was increased. The increase in the activity of lipoprotein lipase as the mediator of hydrolysis of triglyceride in chylomicron causes free fatty acids to generate energy or be stored as fat.