Abstract
Thyroid hormone mediates a variety of physiological effects through thyroid hormone receptors (TR). Because of the diversity of thyroid hormone response elements (TREs) bound by TR, it is difficult to predict genomic regions regulated by TR ab initio. In this study, we have performed a comprehensive analysis of TR bindign sites in the genome using a novel chromatin IP-Sequencing strategy, employing a biotinylated epitope tag ( BioChIP-Seq). Using this strategy, we have discovered that thyroid hormone receptor binds to a wider diversity of promoter sequences than expected and exhibits unexpected changes in response to hormone binding.
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