Abstract
l-Leucine modified voriconazole spray dried micropartcles.
Highlights
The lung represent an attractive portal for the delivery of drugs for the treatment of local pathological conditions and for the systemic delivery of drugs, proteins and peptides in order to exert systemic pharmacological actions.[1,2] Traditionally, pressurized metered dose inhalers have been the device of choice for the aerosolized delivery of drugs
Low dose delivery and use of propellants are some of the drawbacks of pressurized metered dose inhalers (pMDIs) which led to innovations in other pulmonary delivery systems.[3]
When spray dried of its own (Fig. 3A) VRZ was found to present a plate like crystalline morphology
Summary
The lung represent an attractive portal for the delivery of drugs for the treatment of local pathological conditions and for the systemic delivery of drugs, proteins and peptides in order to exert systemic pharmacological actions.[1,2] Traditionally, pressurized metered dose inhalers (pMDIs) have been the device of choice for the aerosolized delivery of drugs. Low dose delivery and use of propellants are some of the drawbacks of pMDIs which led to innovations in other pulmonary delivery systems.[3] Dry powder inhalers are of particular interest to pharmaceutical research and industry owing to their ability to deliver large doses of drug, ease of administration, short. The primary consideration for the inhaled drug particles is their aerodynamic particle size should lie in the range of 1–5 mm. Powders in this size range generally exhibit highly cohesive behavior and a tendency to aggregate limiting their utility as inhalable dry powder formulations.[5,6] it is imperative to control particle cohesion so as to improve the dispersibility of dry powder formulations
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