Abstract
We investigated the perioperative changes in immunological function of monocytes in patients with gastric or esophageal carcinoma in terms of surface antigen HLA-DR and serum cytokine IL-6 and IL-8 levels. Subjects were 16 cases of curatively resected gastric carcinoma, seven cases of non-curatively resected gastric carcinoma, three cases of curatively resected and four cases of non-curatively resected esophageal carcinoma. Six cases received laparoscopic cholecystectomy for cholecystolithiasis were served as control. Peripheral blood samples were collected from them on the day before operation, 1st, 3rd, 5th, 7th and 14th postoperative day. Of these samples, the mean fluorescence intensity (MFI) of surface antigen HLA-DR expressed on monocytes were analyzed by FACScan, and serum cytokines were analyzed by ELISA. In patients with gastric carcinoma no significant difference in the MFI of HLA-DR was noted between curatively resected and noncuratively resected groups, but in noncuratively resected group it was significantly lower on 14th postoperative day than that of preoperative day. In patients with esophageal carcinoma, there was no significant difference in the MFI of HLA-DR between curatively resected and noncuratively resected groups on the preoperative day, but in curatively resected group it significantly increased on the 3rd postoperative day. Serum IL-8 level in noncuratively resected gastric carcinoma group was significantly higher than those of curatively resected group on preoperative day and the 1st postoperative day. Serum IL-8 level in noncuratively resected esophageal carcinoma group was significantly higher than that of curatively resected group in perioperative period. These results suggest that patients with noncuratively resected esophageal carcinoma have fallen into the state of immunosupression of monocytes.
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