Abstract
Background: Despite the widespread consumption of iodide in the United States, large nodular goiter remains a common problemand its pathogenesis is incompletely understood. Methods: Potential factors involved in the pathogenesis of large unilateral (≥ 50g) and bilateral (≥100g) nodular goiter were investigated including: age, gender, race, body mass index (BMI), family history of thyroid disease, insurance status, cigarette smoking, and alcohol use. Data were obtained from an IRB-approved thyroid database and retrospective chart review of consecutive patients operated on for nodular goiter from 1990-2004.
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