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Abstract
The responsiveness of prejunctional α 1-, and postjunctional α 2-adrenoceptors was examined in human isolated saphenous veins from male patients in the age range 37–70. There was no age-related alteration in the prejunctional potency of the α 2-adrenoceptors agonist xylazine for inhibiting the stimulation-evoked overflow of tritium in tissues preincubated with [ 3H]noradrenaline. The α 2-adrenoceptor antagonist yohimbine (0.01–1 μM) and the α 1-adrenoceptor antagonist prazosin (0.1–1 μM) signifcantly reduced stimulation-evoked contractions in a concentration-dependent manner. There was no significant age-related correlation for the potency of prazosin but there was a significant negative correlation between the potency of yohimbine and age (r = 0.70, n = 11, P < 0.05), i.e. the potency of yohimbine decreased with increasing age. The decreased postjunctional potency of yohimbine may reflect a loss of α 2-adrenoceptors with increasing age.
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