Abstract
SUMMARY Propofol, an intravenous (iv) anaesthetic agent, was given to 12 long-tailed macaque monkeys (Macaca fascicularis) that were initially chemically restrained using ketamine hydrochloride. Anaesthesia was induced and maintained using incremental iv injections of propofol at various dose rates. Physiological parameters were monitored during anaesthesia. Five animals were allowed to recover from anaesthesia and their recovery was usually uneventful. At the dose levels investigated there was good muscle relaxation and analgesia and cardiovascular and respiratory functions were adequately maintained. A dose of 10 mg/kg bodyweight gave moderate surgical anaesthesia for between 20 and 40 mins.
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