Abstract
Male fertility and reproductive health are major concerns in a modern society. Male infertility and prostate cancer can seriously affect life quality and life expectancy. This thesis focused on the roles of cysteine-rich secretory proteins (CRISPs) family proteins in male fertility and prostate cancer by using Crisp1 and Crisp4 double knockout (DKO) and Hi-MYC+Crisp3-/- mouse models. In the epididymis, CRISP1 and CRISP4 function cooperatively, and autonomously, in maintaining optimal sperm functions. CRISP3 plays a pro-tumorigenic role in prostate cancer, through modulation of key factors associated with cell-cell adhesion, thus promoting the transition from carcinoma in situ to invasive carcinoma.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
