Abstract
AbstractThe solubility of xanthine in cold aqueous solutions has been reinvestigated in view of conflicting values given in the literature. A significant factor, not appreciated by earlier workers was that, unlike related oxopurines, only a small difference exists between the first acidic pKa of this purine and neutral pH. Thus, in view of the highly insoluble nature of the neutral molecule, compared with the very soluble anionic form, the solubility in this region is highly pH dependent. Other factors found which may have a bearing on solubility results are supersaturation effects and the formation of colloidal solutions. Some possible consequences of the solubility phenomena in pathological conditions in which xanthine metabolism is concerned are discussed.
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