Abstract
Ischaemic conditioning is the cardioprotective process of exposing the heart to short periods of ischaemia and reperfusion in order to increase its survivability when encountered with a subsequent sustained period of lethal ischaemia. Mitochondria undergo fusion and fission processes and potentiating mitochondrial fission has been reported to be linked to increased cell death.
Highlights
Background/Introduction Ischaemic conditioning is the cardioprotective process of exposing the heart to short periods of ischaemia and reperfusion in order to increase its survivability when encountered with a subsequent sustained period of lethal ischaemia
Hypoxic pre-conditioning does not seem to be inducing mitochondrial fusion as Mouse embryonic fibroblasts (MEFs) exposed to the pre-conditioning protocol only, showed a 16% ± 2.1% decrease in mitochondrial fusion
Discussion/Conclusion This study demonstrates that ischaemic pre-conditioning can be replicated in a cell line and that it appears to be preventing cell death by inhibiting mitochondrial fission
Summary
Background/Introduction Ischaemic conditioning is the cardioprotective process of exposing the heart to short periods of ischaemia and reperfusion in order to increase its survivability when encountered with a subsequent sustained period of lethal ischaemia. An investigation into the effects of simulated ischaemic preconditioning on mitochondrial fusion in mouse embryonic fibroblasts Ernest J Chew*, Andrew R Hall, Niall F Burke, Derek J Hausenloy, Derek Yellon From World Society of Cardiothoracic Surgeons 25th Anniversary Congress, Edinburgh Edinburgh, UK.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
