Abstract
Ischaemic conditioning is the cardioprotective process of exposing the heart to short periods of ischaemia and reperfusion in order to increase its survivability when encountered with a subsequent sustained period of lethal ischaemia. Mitochondria undergo fusion and fission processes and potentiating mitochondrial fission has been reported to be linked to increased cell death.
Highlights
Background/Introduction Ischaemic conditioning is the cardioprotective process of exposing the heart to short periods of ischaemia and reperfusion in order to increase its survivability when encountered with a subsequent sustained period of lethal ischaemia
Hypoxic pre-conditioning does not seem to be inducing mitochondrial fusion as Mouse embryonic fibroblasts (MEFs) exposed to the pre-conditioning protocol only, showed a 16% ± 2.1% decrease in mitochondrial fusion
Discussion/Conclusion This study demonstrates that ischaemic pre-conditioning can be replicated in a cell line and that it appears to be preventing cell death by inhibiting mitochondrial fission
Summary
Background/Introduction Ischaemic conditioning is the cardioprotective process of exposing the heart to short periods of ischaemia and reperfusion in order to increase its survivability when encountered with a subsequent sustained period of lethal ischaemia. An investigation into the effects of simulated ischaemic preconditioning on mitochondrial fusion in mouse embryonic fibroblasts Ernest J Chew*, Andrew R Hall, Niall F Burke, Derek J Hausenloy, Derek Yellon From World Society of Cardiothoracic Surgeons 25th Anniversary Congress, Edinburgh Edinburgh, UK.
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