Abstract
The present study utilised the direct compression method to formulate orodispersible tablets of Clozapine using various natural superdisintegrants such as plantago Ovata mucilage and unripe banana powder at various concentrations (2 percent, 4 percent, 6 percent, and 8 percent) and a control formulation (without superdisintegrants). To increase the mouth feel, microcrystalline cellulose and mannitol were employed. The pre compression characteristics of the prepared formulations were determined, and all formulations were found to have satisfactory flow qualities. After compression, the tablets were examined for hardness, friability, homogeneity of drug content, wetting time, water absorption ratio, in vitro dispersion time, and dissolving studies. CLZ4 containing 8% plantago ovata mucilage had a faster in vitro dispersion time (9 seconds), disintegration time (13 seconds), wetting time (10 seconds), and drug release rate (99%) in 30 minutes. Stability analyses conducted on the promising formulations revealed no significant changes in drug content or in vitro dispersion time. There are no drug-excipient interactions, as determined by IR spectroscopy.
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