Abstract
In addition to the well-established effects of corticotrophin-releasing factor (CRF) synthesized in the hypothalamic paraventricular nucleus in modulating the stress response, CRF has also been implicated in a number of other functions. In particular both pro- and anti-inflammatory effects have been proposed for CRF. In the present study we have investigated the effects of 14 day peripheral infusion of CRF on the development of adjuvant-induced arthritis (AA) in the rat. To avoid confounding effects of the CRF stimulating endogenous corticosterone, all animals in the study were adrenalectomized. We were unable to determine any effect of the treatment at either of the doses of CRF investigated. The bioactivity of the CRF was confirmed in vitro and the presence of substantial circulating levels of CRF in plasma in the high dose group at time of sacrifice suggest that the CRF was successfully infused over the 14 day experimental period. These data suggest that CRF is not important in the mediation of AA. Alt...
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