Abstract
BackgroundGenetic polymorphisms play a crucial role in the development of osteonecrosis of the femoral head (ONFH). This study mainly explored the association of IL-6 variants and ONFH susceptibility among the Chinese Han population.MethodsTwo variants (rs2069837, and rs13306435) in the IL-6 gene were identified and genotyped from 566 patients with ONFH and 566 healthy controls. The associations between IL-6 polymorphisms and ONFH susceptibility were assessed using odds ratio (OR) and 95% confidence interval (95% CI) via logistic regression. The potential function of these two variants was predicted by the HaploReg online database.ResultsThe results of the overall analysis revealed that IL-6 rs2069837 was correlated with decreased risk of ONFH among the Chinese Han population (p < 0.05). In stratified analysis, rs2069837 also reduced the susceptibility to ONFH in older people (> 51 years), males, nonsmokers, and nondrinkers (p < 0.05). However, no associations between rs13306435 and ONFH susceptibility were observed (p > 0.05).ConclusionsTo sum up, we suggested that rs2069837 G>A polymorphism in the IL-6 gene was significantly associated with a decreased risk of ONFH among the Chinese Hans. These findings underscored the crucial role of IL-6 rs2069837 in the occurrence of ONFH.
Highlights
Genetic polymorphisms play a crucial role in the development of osteonecrosis of the femoral head (ONFH)
Osteonecrosis of the femoral head (ONFH) refers to the death of some osteocytes or the necrosis of some marrow elements caused by venous congestion, impairment or interruption of arterial blood, and subsequent repair, which in turn causes the necrosis of bone tissues [1]
We aimed to investigate the effect of IL-6 rs2069837 and rs13306435 polymorphisms on ONFH susceptibility among Chinese Hans
Summary
Genetic polymorphisms play a crucial role in the development of osteonecrosis of the femoral head (ONFH). The number of ONFH patients is increasing worldwide year by year [2]. The incidence of ONFH was 2.91 cases per 100,000 person-years in the Japanese population [3]. Based on Chinese population data from 2010, there are approximately 8.12 million cases of ONFH among Chinese people aged 15 years and over [5]. It poses a severe financial burden for both individuals and healthcare systems.
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